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Embattled Alzheimer’s Researcher Is Charged With Fraud


A scientist whose analysis has been on the middle of controversy over an Alzheimer’s drug candidate has been charged with fraud.

A federal grand jury on Thursday indicted Hoau-Yan Wang, a professor on the Metropolis Faculty of New York, on costs of falsifying information to acquire grants totaling roughly $16 million from the Nationwide Institutes of Well being.

Dr. Wang’s research underpinned analysis right into a diagnostic take a look at for Alzheimer’s illness and simufilam, a drug in superior medical trials. Simufilam’s producer, Cassava Sciences, a pharmaceutical firm primarily based in Texas, has mentioned the drug improves cognition in Alzheimer’s sufferers.

Alzheimer’s illness impacts roughly six million Individuals — a quantity that’s anticipated to double by 2050 — and promising therapies generate great pleasure. Cassava’s inventory soared after every spherical of reported outcomes from its trials.

However some scientists had publicly disparaged the drug, saying its mechanism of motion and purported outcomes have been implausible. Some went additional and accused the corporate and Dr. Wang, its scientific marketing consultant, of manipulating outcomes. A number of journals retracted or connected statements of concern to publications by Dr. Wang and a co-author at Cassava.

After the indictment was introduced on Friday, Cassava’s inventory plummeted to its lowest value since October 2020.

Remi Barbier, the founder and chief government of Cassava, didn’t instantly reply to a request for remark. However in a assertion posted on its web site, the corporate mentioned Dr. Wang’s work “was associated to the early improvement phases of the corporate’s drug candidate and diagnostic take a look at.”

“Dr. Wang and his former public college medical faculty have had no involvement within the firm’s Part 3 medical trials of simufilam,” the assertion mentioned.

A publicist for the corporate pointed to a September 2023 publication that he mentioned supplies “impartial verification of the science.”

An investigation by the Metropolis College of New York, of which the faculty is part, struggled for months to acquire entry to Dr. Wang’s recordsdata. Finally, members of the investigating committee concluded that Dr. Wang had been “reckless” in his failure to maintain or present authentic information, an offense that “quantities to important analysis misconduct.”

Neither the faculty nor Dr. Wang instantly responded to requests for touch upon the indictment.

Dr. Wang is now accused of falsifying information in grant functions over practically eight years ending in April 2023, based on the Justice Division. Among the grants funded Dr. Wang’s wage and laboratory analysis on the college.

Federal prosecutors charged Dr. Wang with a number of counts of fraud and false statements. If convicted, he faces a most jail sentence of 55 years.

The Federal Bureau of Investigation’s Washington discipline workplace is investigating the case. The indictment was handed down in Maryland, the place the N.I.H. is predicated.

In an emailed assertion, Renate Myles, a spokeswoman for the N.I.H., mentioned the company “doesn’t talk about grants compliance critiques on particular funded awards, recipient establishments or supported investigators.”

“Nonetheless, N.I.H. takes analysis misconduct very significantly,” she mentioned. “N.I.H. promptly and thoroughly critiques all allegations of analysis misconduct obtained.”

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