Dimethyl sulfoxide (DMSO) is a remarkably secure1 naturally occurring compound that may deal with quite a lot of difficult circumstances. Since DMSO is extremely efficient for treating continual ache, arthritis, and accidents like sprains or burns2 (mentioned additional right here), it rapidly unfold throughout America as a miracle drug.
1000’s of research have been performed to verify its worth, and earlier than lengthy, lots of of 1000’s of individuals thought of it to be a very powerful therapeutic ever found. Sadly, as a result of politics, the FDA turned in opposition to DMSO and refused to relent3 even as soon as:
• DMSO was proven to successfully deal with strokes, traumatic mind accidents, spinal twine accidents, and lots of circulatory problems (mentioned right here).
• DMSO was proven to remedy quite a lot of “incurable” autoimmune and connective tissue problems (mentioned right here).
• DMSO was proven to deal with quite a lot of difficult (and infrequently incurable) eye, ear, sinus, and dental circumstances equivalent to tinnitus and blindness (mentioned right here).
Since publishing these articles, I’ve acquired over a thousand studies from individuals of the exceptional results DMSO has had on them (which might be learn right here), that whereas unbelievable, are virtually an identical to what individuals throughout America reported earlier than the FDA buried DMSO.
Reversing Organ Degeneration
The next course of underlies many illness states:
In fast circumstances, that is simple to acknowledge (as cells will quickly die after a traumatic harm or having their blood provide reduce off), whereas in slower circumstances (e.g., these arising from a continual sickness or toxicity), the problem usually is that the mobile restore course of turns into frozen and unable to carry the cells again to regular functioning.
Many regenerative medical therapies in flip, search to “unfreeze” this cell hazard response in order that the conventional operate of the cells might be restored.
DMSO is uniquely suited to reversing this course of as, particularly when executed early within the fast circumstances following a extreme harm (whereas the extra gradual and continual ones we frequently see steadily require systemic regenerative remedy). It is because:
1. DMSO protects the blood provide of the physique,4 and disperses the microclotting, which regularly follows harm (e.g., burns) and results in tissue loss of life.5 Concurrently, it additionally protects tissues from dying in periods of insufficient blood provide (ischemia) or being injured when that blood provide is quickly restored (reperfused).
Quite a few animal research have demonstrated DMSO’s protecting impact in organs that quickly die as soon as they lose their blood provide, equivalent to the guts6,7,8,9,10,11,12 and mind13,14,15,16,17,18,19,20,21,22,23 (and even DMSO sustaining their operate24,25,26 in periods of ischemia).
Likewise, DMSO has additionally been proven to forestall ischemia and reperfusion accidents to the liver27,28 kidney,29,30,31,32 lungs,33,34 ovaries35 and small gut.36
2. DMSO protects organs from toxins that will in any other case be deadly to them or completely injury them. This has been proven with the guts,37 kidneys,38,39,40 liver41,42,43,44 lungs,45 pancreas.46,47,48 Moreover, DMSO has additionally been repeatedly proven to mitigate radiation injury to tissues (e.g., within the kidneys).49
3. DMSO has been proven to guard the mind50,51 liver,52 and lungs53 from the tissue injury that develops after blunt trauma or surgical excisions.
Word: This was additionally repeatedly demonstrated in people with extreme blunt head trauma.54,55,56
4. DMSO dampens the harmful autoimmune course of and swelling that always follows tissue trauma.57,58 Along with defending organs from harm, and reversing that degenerative course of, DMSO has additionally been proven to assist with quite a lot of difficult medical circumstances.
Coronary heart
Nearly all of the pertinent research evaluating DMSO’s interactions with the guts (e.g., the beforehand talked about ones) evaluated its skill to guard the guts from ischemic occasions like coronary heart assaults and to enhance the circulation throughout the physique.59
Gastrointestinal Tract
Quite a few randomized managed trials performed in Iraq discovered DMSO was extremely helpful for gastrointestinal illnesses:
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One evaluated 136 sufferers with recurrent assaults of proctosigmoid ulcerative colitis that weren’t being prevented by their prophylactic medical routine. For these receiving commonplace care, 51% recovered in two weeks in comparison with 84% of these additionally receiving DMSO. Over the subsequent yr, 25% of these persevering with to obtain commonplace care had a relapse charge, whereas solely 5% of these receiving DMSO did.60 |
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One evaluated hospitalized sufferers with pelvic fractures or hypovolemic shock who have been in danger for a stress induced gastric ulcer. Of the 58 controls, 22% developed an ulcer, whereas of the 57 receiving DMSO, solely 4% did. Moreover, none of these receiving DMSO deteriorated or required emergency surgical procedure, whereas 8 controls and 1 allopurinol recipient did (of whom 3 then died).61 |
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One evaluated 302 consecutive sufferers with earlier symptomatic duodenal ulceration that was proven to have healed, and who have been people who smoke and social drinkers, to obtain 4 completely different remedies. Of the 220 obtainable for analysis, 65% who acquired a placebo had a recurrence of the ulcer, 30% of those that acquired cimetidine, and 13% of those that acquired oral DMSO.62 Word: Comparable outcomes have been obtained by American physicians in a smaller variety of sufferers.63 |
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One evaluated 363 consecutive sufferers whose duodenal ulcers that didn’t heal regardless of 3 months of remedy with cimetidine (and who have been cigarette people who smoke or social drinkers), got both cimetidine twice a day alone or with DMSO or allopurinol. In 315 sufferers who have been evaluable for evaluation, at 8 weeks, 60% of those that had cimetidine recovered, whereas 100% of those that acquired DMSO recovered. Moreover, the one yr relapse charge was 29% for cimetidine alone and seven% in those that took DMSO.64 |
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One evaluated 238 sufferers with symptomatic acute duodenal ulceration who have been people who smoke and social drinkers have been randomized to obtain for 8 weeks cimetidine or 8 weeks of a half dose of cimetidine plus oral DMSO (400mg two instances a day) or allopurinol. After 8 weeks, 69 of the 87 (79%) who solely acquired cimetidine recovered, whereas the entire 85 who acquired DMSO did. Moreover, 67% of those that acquired cimetidine over the subsequent yr relapsed, in comparison with 6% of those that took DMSO.65 |
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One evaluated 101 sufferers presenting with hematemesis (coughing up blood) as a result of erosive gastritis (a reasonably harmful situation). It gave them both saline or oral allopurinol and DMSO orally each 6 hours for five days. Of the 50 controls and 48 who have been handled (together with 2 who left as a result of they may not tolerate the remedy), 29% of the controls and eight% of who have been handled had additional episodes of hematemesis (with three of the controls requiring subsequent surgical procedure — one in all whom died). Of those that remained steady, a subsequent endoscopy confirmed proof of hemorrhagic irritation in 44% of controls and 9% of those that have been handled.66 Lastly, DMSO additionally has been proven to assist with irritable bowel syndrome, acute or continual gastritis, peptic ulcers, enterocolitis, and mucomembranous colitis.67 |
Liver
Along with DMSO defending the liver from harm, DMSO can generally heal the liver. For instance, 12 sufferers who had terminal liver cirrhosis who agreed to cease consuming all alcohol at some point of this system have been placed on each day DMSO program.
Of the 8 who selected to proceed this system for six months, all had improved well being, considerably lowered vomiting, and improved liver operate checks, and somewhat than all being lifeless inside one yr as anticipated, they have been in higher situation than that they had been at the beginning of the examine.68
Gallbladder
- A rat examine created obstructive jaundice by ligating (reducing off) the widespread bile ducts and located that laboratory values confirmed DMSO mitigated the anticipated pathologic results.69
- A Japanese examine discovered that injecting 90% DMSO blended with 5% hexametaphosphate into the biliary tract successfully dissolved gallstones throughout the liver and was secure for the sufferers.70
Lungs
Extra knowledge helps the protecting function of DMSO for the lungs:
• After sheep skilled a lung harm from inhaling smoke, nebulized DMSO (with heparin) was discovered to cut back the injury to their lungs considerably.71
Word: Some unresolved questions exist relating to the protection of long run DMSO nebulization.72
• DMSO was discovered to forestall oxygen deprivation and incapability to alternate gasses by way of the lungs which ends up from an Ehrlichia ruminantium an infection (which is usually deadly).
DMSO has additionally been proven to deal with acute respiratory misery syndrome (ARDS), a difficult situation that steadily leads to being positioned on a ventilator (e.g., this occurred all through COVID-19).
In a hamster examine and a mouse examine, the place a toxin was used to induce ARDS, DMSO considerably lowered the ensuing lung injury and fluid leakage (which successfully drowns ARDS sufferers).73,74 A 3rd mouse examine discovered DMSO prevented all of them from dying (whereas 58% of controls died).75
Within the one human examine the place IV DMSO was used for ARDS (given intravenously at concentrations beneath 10%) it was discovered to supply a dramatic enchancment in all three sufferers who acquired it (e.g., one affected person’s lungs have been utterly regular after per week) and previous to receiving DMSO all three have been close to loss of life.76
Word: Within the one case when DMSO was nebulized, the advance occurred in 1 hour.
Lastly, DMSO will help continual lung circumstances.
• One examine discovered DMSO reduces continual pulmonary fibrosis, and this helpful impact was elevated when it was blended with zinc.77
• For older sufferers with continual respiratory insufficiency (resulting in chronically low blood oxygen ranges, elevated carbon dioxide ranges and an irregular acid base steadiness, particularly throughout workout routines) as a result of points within the lungs or bronchi, DMSO was discovered to carry a couple of restoration with out the necessity for hospitalization in 35/43 (81%).78
• Human research even have proven DMSO can deal with bronchial asthma.79
Pancreas and Diabetes
Diabetics have reported that DMSO reduces (however doesn’t remove) their want for insulin and that DMSO is especially useful for the situation since it might probably additionally alleviate the ache from diabetic peripheral neuropathy.80 Research on this space embrace:
• Alloxan is poisonous to the insulin producing cells of the pancreas and can be utilized to induce diabetes. A 1977 examine discovered that DMSO prevented alloxan from inflicting diabetes.81
• DMSO has been proven to forestall the immune system from attacking transplanted insulin secreting cells (suggesting DMSO has vital potential for Sort 1 diabetes).82
• GLP-1 is a key hormone the physique makes use of to control satiety and blood sugar (and which diabetes medicine like Ozempic mimic). One examine discovered that 0.5% to 2.5% DMSO elevated GLP-1’s manufacturing of insulin by 2 to 2.5 instances. This means DMSO might assist deal with diabetes or enable GLP-1 customers to make use of a decrease dose of the remedy.83
• Exposing insulin secreting cells to DMSO was discovered to reinforce glucose-induced and tolbutamide-stimulated insulin secretion with out vital results on basal secretion or potassium responsiveness.84
DMSO (together with ultraviolet blood irradiation) has additionally been proven to assist pancreatitis, a difficult and harmful situation85 (as there are not any typical remedies moreover supportive care for many sorts of pancreatitis). For instance, three rat and mice research discovered DMSO considerably improved experimentally induced pancreatitis.86,87,88
Moreover, a randomized double-blind trial took 78 sufferers with continual recurring pancreatitis (and no different confounding gastrointestinal problems) who offered inside 2 hours with indicators of pancreatitis however didn’t have indicators of generalized peritonitis. Of them, 26 acquired 10% DMSO rectally, and not less than 57% have been freed from ache after 12 hours (in comparison with 17% of controls), and all have been freed from ache after 24 hours (whereas 48% of controls have been nonetheless in ache).
Because of this, all DMSO topics have been discharged inside 3 days, whereas solely 22% of controls have been discharged after 5 days of hospitalization.89
Kidneys
In most circumstances, DMSO has been proven to be secure for the kidneys, to operate as a potent diuretic, and to extend the kidney movement charge.90 Along with defending the kidneys from ischemia and toxins like mercury, many research have additionally proven DMSO protects the kidneys from amyloidosis.91
Many kidney autoimmune illnesses end result from immune deposits within the kidneys (one in all which is Heymann nephritis, an experimentally induced type of nephritis92 the place antibodies that concentrate on the kidneys are injected inflicting immune deposits on the glomerular partitions). In three rat research of Heymann nephritis, DMSO was discovered to guard the kidneys and their operate.93,94,95
Equally, a examine of 56 DMSO handled rats (and 48 controls) with lupus nephritis discovered that those that acquired DMSO had almost regular kidneys, whereas the controls had vital injury to their kidneys.96 DMSO, possible as a result of its results on zeta potential,97 has additionally proven promise for kidney stones:
• A examine fed rats a weight loss program designed to create kidney stones, and located that after two months, 40 of the 45 water-drinking rats had developed stones within the kidney, bladder or ureter, whereas solely 11 of the 46 DMSO group did.98
• A examine of 6 sufferers with kidney stones (5 of which have been confirmed by ultrasound) discovered IV DMSO99 resolved the situation in 2 to three remedies (though one affected person had a whole decision after a single infusion).100
Word: Now we have had an excessive amount of success treating kidney stones by bettering the physiologic zeta potential.
Genitourinary Issues
DMSO is extraordinarily useful for irritation of the bladder, notably “interstitial cystitis” (also called painful bladder syndrome), a difficult situation which leads to very frequent, painful (and infrequently bloody) urination. DMSO, nonetheless may assist many different elements of the urinary tract. For instance one examine discovered:101
Likewise, a examine of inflammatory circumstances of the urinary tract, along with displaying vital profit for interstitial cystitis, additionally discovered:102
• Of the 12 sufferers with radiation cystitis (e.g., from prostate most cancers remedy) 50% had response to it.
• Of the 35 sufferers with continual prostatitis, 75% benefited considerably, with 12 having an “glorious” response, 14 a “good” response, and in 90% of circumstances, irritation of the prostatic urethra improved.
• One other examine gave 4 males with continual extreme (and untreatable) urination as a result of bladder or prostate points DMSO, 3 of whom had a wonderful response.103
• A Polish examine discovered urethral syndrome (continual irritation of the urethra with out indicators of an an infection) responds to DMSO being put into the urethral tract.104
Word: Many different exceptional studies exist of DMSO’s worth for prostatitis (e.g., one DMSO physician not too long ago shared that it handled 40 out of 40 circumstances of bacterial prostatitis).105
Moreover, whereas no formal research have been performed on prostate enlargement many anecdotal studies (together with from readers of the Forgotten Aspect of Medication) have discovered DMSO is remarkably helpful for this situation.106
Reproductive Issues
• A 1975 Chilean examine at a Navy hospital took 69 girls who have been infertile as a result of an obstruction of their fallopian tubes and injected a DMSO combination into their fallopian tubes six separate instances (after which repeated the sequence if the tubes had not opened). Out of 47 sufferers, 27 (57.4%) subsequently turned pregnant, together with one who bought pregnant twice (with none additional help).
Of the 27 pregnancies, 12 resulted in profitable deliveries, 7 had a traditional being pregnant on the time of publication, 4 sufferers selected to have abortions, and three had spontaneous abortions, and 1 had an irregular being pregnant requiring a surgical intervention, and 0 had ectopic pregnancies (one of many dangers of surgically opening the fallopian tubes).
Moreover, out of the 426 DMSO hydrotubations which have been carried out, solely 7 (1.5%) had unintended effects all of which have been minor.107
Word: 25% to 35%108 of infertility is because of tubal obstructions (usually from irritation there). The present surgical strategy for opening a tubal obstruction and restoring fertility (which bears some dangers) has a ten% to 30%109,110 success charge.
• One examine administered 10% to 30% DMSO into the uteruses of horses that would not get pregnant. It discovered no hurt occurred to the liner of the uterus and that 18 out of 27 had vital enchancment to the liner of their uterus (in comparison with 2 out of 18 who acquired a saline placebo), equivalent to a discount of continual inflammatory cell infiltrates and discount of periglandular fibrosis.
Moreover, there have been indicators their fertility improved, however the trial’s design made it not possible to make certain this enchancment occurred.111
A New Therapeutic Precept
When DMSO was found, Stanley Jacob rapidly realized that it represented a brand new therapeutic precept because it made so many issues which had beforehand appeared not possible in medication out of the blue doable — and much more remarkably, 60 years later, lots of the issues DMSO can tackle the medical system nonetheless struggles to cope with.
For instance, in the identical approach DMSO might considerably enhance surgical outcomes,112 the info right here makes good case that DMSO must be a mainstay remedy each time somebody is vulnerable to organ failure from being poisoned (e.g., as a result of a drug overdose). Likewise, the info right here reveals how quite a few immensely difficult illnesses that require a hospital or intensive care admission could possibly be dramatically improved with DMSO.
Nonetheless, whereas the FDA’s battle in opposition to DMSO was immensely unlucky, I’m extraordinarily hopeful the unprecedented political local weather we at the moment are getting into we are going to ultimately make it doable to reform a medical system that has at all times put earnings earlier than individuals.
A lot of that’s because of the unbelievable work lots of you have got executed all through the pandemic to carry consciousness to the crimes of the medical industrial advanced and I’m profoundly grateful to every of you for serving to to make it occur and giving me the voice to as properly.
Creator’s be aware: That is an abridged model of an extended article that goes into better element on the info mentioned right here, how DMSO is used for every of the circumstances talked about (together with different approaches we’ve seen assist them), and offers steerage for private DMSO use (e.g., dosing, therapeutic precautions and the place to acquire it). That article and its extra references might be learn right here.
A Word from Dr. Mercola Concerning the Creator
A Midwestern Physician (AMD) is a board-certified doctor from the Midwest and a longtime reader of Mercola.com. I admire AMD’s distinctive perception on a variety of matters and am grateful to share it. I additionally respect AMD’s need to stay nameless since AMD continues to be on the entrance strains treating sufferers. To search out extra of AMD’s work, you should definitely try The Forgotten Aspect of Medication on Substack.
